This Web Site is committed to the memory of Janis Morrow.
VX950 Protease Inhibitor Telaprevir
2008
Oct-Sept
See Below: Denise is SVR Treating With Protease Inhibitor Telaprevir Vertex-950
On this Web Site : Terry was in the boceprevir trial 6 mth SVR!!
Or read it on our Forum : TERRY boceprevir trial six month SVR
Vertex CEO preparing for '09 early telaprevir hepatitis C drug launch -
Vertex Reports 52% SVR 12 Rate for a 24-week Telaprevir-based Regimen in Genotype 1 Hepatitis C Patients Who Failed Prior Treatment -
EASL 2008-New Drugs Bottom Line
May-April
Vertex reports promising hepatitis C drug results
Vertex Telaprevir HCV Protease Inhibitor Could Be A Winner; 2.5 million untreated/undiagnosed
Vertex to Start Phase 3 Trials of HCV Protease Inhibitor Telaprevir (VX-950) - 2/01/08
Denise Treating With Protease Inhibitor Telaprevir Vertex-950
Read more on our message boards
I can't believe I only have 3 days of Riba left! It was so great to fill up my pill dispenser for the week and be able to leave some days empty!!!
It's been a rough ride(who's treatment isn't?!?) but if I can hold onto that UD it will all have been worth it.
Iam1a, Stage2, Grade 1-2. I was in a 48 week arm. The first 24 weeks I took the standard treatment as well as the Telaprevir. The last 24 weeks have been standard treatment only.
They did not allow rescue drugs in the Prove 3 trial and I became anemic real quick...just like the last time I treated. Since Procrit wasn't an option they had to dose reduce/discontinue my Riba for most of the trial. I was only on full dose Riba for a few of the 48 weeks. It's been shown that Riba is a necessary part of the cocktail so I was VERY nervous. I wasn't able to get any VL results until my 24 week results. At that time I found out that I went from 12,500,000 on my start date to <30 by week 4! The first time I treated with SOC I didn't have a 2 log drop by week 13 and stopped. At that time I started with a much lower VL of 2,380,000. That just give's you an idea of how powerful these PI's are.
Vertex is continuing trails with the Telaprevir as well as 2 other PI's.
Vertex has submitted some late extracts regarding Prove 3 preliminary results to be presented at the EASL meeting in April. I have a feeling it's going to be more great news from Vertex.
I learned everythingI needed to get me through the past 48 weeks right here on J&F and will always be grateful for this site and the people here.
I owe Karen a huge debt of gratitude. She has been there for me every day and when I didn't feel like talking to ANYONE, Karen was the exception. Thank you my friend. Now, we need to get you on a PI so we can start planning that trip!
A friend of mine has declared Thursday as "All bad things gone and only good things to come,day!";-)
Thanks again to everyone for the well wishes and hope to start posting again as my system starts to clear.
If anyone has any questions about the Prove 3 trail feel free to email me through my profile.
BTW, I LOVE VERTEX!!!
Denise...next stop SVR...
UPDATE April 30th 08
|
2007-2006
Telaprevir plus Pegylated Interferon
Is Effective against Both Wild-type and Drug-resistant HCV Strains
-
8/17/07
Mutations That Confer Resistance to HCV Protease
Inhibitors
5/01/07
Telaprevir-based
Therapy for HCV May Shorten Treatment Duration from 48 to 24 Weeks for Some
Genotype 1 Patients
-
4/17/07
In Vitro Studies Suggest Promising Outcomes with New
HCV Protease Inhibitor ACH 806 in Combination with Interferon, Telaprevir,
or NM 107
4/05/07
Telaprevir
Demonstrates Safety and Anti-HCV Activity in 12-week Interim Analysis
1/05/07
Telaprevir
Resistance Mutations Observed in Laboratory Studies
12/05/06
Updated Results from Patients Receiving Standard HCV
Therapy Following Telaprevir
12/01/06
Telaprevir plus
Pegylated Interferon Suppresses Wild-type and Resistant HCV Over 14 Days
11/03/06
Rapid Decline of HCV RNA in Patients Treated with
VX-950
10/02/06
12 of 12 Patients Receiving Experimental HCV Protease
Inhibitor VX 950 in Combination with Pegasys Plus Ribavirin for 28
Days Experience Undetectable HCV RNA Levels-
5/23/06
Small Study Shows HCV RNA Levels Undetectable in 12 of
12 HCV Genotype 1 Patients after 4 Weeks of Treatment with Experimental HCV
Drug VX 950 Plus Pegasys and
Ribavirin
-
2/10/06
Experimental Oral Protease Inhibitor VX-950
from Vertex Produces Rapid and Dramatic Reduction in HCV RNA in
Combination with Pegylated Interferon Alfa-2a (Pegasys)
-
1/10/06