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 2006

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Dec 2006


Insulin resistance and hepatitis C.

Boehringer Ingelheim: entering the hepatitis C arena

Transplantation and viral hepatitis: major progress

Screening, diagnosis, and treatment of hepatitis among homeless, substance abusing women

AASLD 2006 - Complications of Cirrhosis and Portal Hypertension-Variceal Bleeding: Clinical Insights and Implications for Practice

Impact of cirrhosis on outcomes in trauma.

Oglufanide Tested as Potential Hepatitis C Treatment

Hepatitis C Toothbrush Contamination

New Method for Improving HCV/HIV Co-Infection Response

Implications of HCV in Liver Transplantation

Hepatitis C and the damage done, part II

Updated Results from Patients Receiving Standard HCV Therapy Following Telaprevir

HCV Treatment Response Persists after Kidney Transplantation

Different Signaling Pathways in Patients with Hepatitis B and C
 


Nov 2006


Blood or liver problems usually associated with jaundice

Approaches to Liver Biopsy Techniques-Revisited

Does Coffee Drinking Protect Cirrhotic Patients against Hepatocellular Carcinoma


Coverage of 57th Annual Meeting of the American Association for the Study of Liver Disease

  1. AASLD: CPG10101 HCV Toll-Receptor 9 Antagonist Phase II Study results - (11/10/06)
     
     
  2. AASLD: New HBV Drug PMEO-DAPym Active In Vitro Against Drug Resistant Mutants of HBV - (11/10/06)
     
     
  3. AASLD: In Vitro Resistance Studies of AG-021541, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-dependent RNA Polymerase - (11/08/06)
     
     
  4. AASLD: Early predictors of anemia in patients with HCV genotype 1 treated with peginterferon alfa-2a (40KD) plus ribavirin 1000-1200 mg/day - (11/08/06)
     
     
  5. AASLD: PegIntron/RBV Effective for >65 Year Olds - (11/08/06)
     
     
  6. AASLD: New Therapy Significantly Increases Platelet Count - (11/08/06)
     
     
  7. AASLD: Eltrombopag, an Oral Platelet Growth Factor, Facilitates Initiation of Interferon Therapy in Subjects with HCV Associated Thrombocytopenia - (11/08/06)
     
     
  8. AASLD: Merck HCV Polymerase Inhibitor - (11/08/06)
     
     
  9. AASLD: In Vitro Resistance Studies of AG-021541, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-dependent RNA Polymerase - (11/08/06)
     
     
  10. AASLD: Pegasys 270 ug/wk+RBV 1200/1600mg in Difficult To Treat Patients - (11/07/06)
     
     
  11. AASLD: Pegasys Every 5 Days in PegIntron Nonresponders - (11/07/06)
     
     
  12. AASLD: Hispanic Responses to PegIntron/RBV in WIN-R Study - (11/07/06)
     
     
  13. AASLD: LATINO Pegasys Study: early responses - (11/07/06)
     
     
  14. AASLD: Adefovir 3 & 5 Years Followup HBeAg+: safety & efficacy - (11/06/06)
     
     
  15. AASLD: 16 vs 24 weeks Pegasys/RBV for Genotype 2 HCV; Taiwan Study: Week 4 Response & Ribavirin Level/Dose Predicts SVR - (11/06/06)
     
     
  16. AASLD: <400,000 is New HCV RNA Cutoff In genotype 1 with Pegasys/RBV - (11/06/06)
     
     
  17. AASLD: 72 Weeks Pegasys/RBV in Genotype 1 Improves SVR Rate For Patients With Early Viral Response (2 log reduction at wk 12) But HCV RNA >50 IU/mL - (11/06/06)
     
     
  18. AASLD: 72 Weeks Peg/RBV for 'Slow-Responders' Improves SVR Rate - (11/06/06)
     
     
  19. AASLD: 400,000 IU/ml was the best cut-off level between Low VL and High VL - (11/06/06)
     
     
  20. AASLD: The cyclophilin inhibitor DEBIO-025 has a potent dual anti-HIV and anti-HCV activity in treatment-naive HIV/HCV co-infected subjects - (11/03/06)
     
     
  21. AASLD: Entecavir vs Adefovir in HBeAg+ Naives 24 Weeks EARLY Study - (11/03/06)
     
     
  22. AASLD: Ribavirin Dose/Levels Predicts Outcome in Pegasys/RBV ACCELERATE Study Comparing 16 vs 24 Weeks Therapy - (11/03/06)
     
     
  23. AASLD: Week 4 Response Predicts SVR in Pegasys/RBV 16 Week Therapy Study in Genotypes 2/3 - (11/03/06)
     
     
  24. AASLD: Win-R Study: Ribavirin Weight-Base Dosing in High Weight Patients; Treatment Responses to PegIntron/RBV for Elderly Patients and by Patient Ethnicity - (11/02/06)
     
     
  25. AASLD: Weight-Based Ribavirin Improves SVR Rate for Patients >125 kg (275 lbs) - (11/02/06)
     
     
  26. AASLD: Infergen (Consensus Interferon) Phase III DIRECT Study End of Treatment Results - (11/02/06)
     
     
  27. AASLD: Current status of Subjects Receiving Pegays and Ribavirin Follow-On Therapy After 28 Days Treatment with the Hepatitis C Protease Inhibitor Telaprevir (VX-950), Pegasys & RBV - (11/02/06)
     
     
  28. AASLD: Win-R Study: Ribavirin Weight-Base Dosing in High Weight Patients; Treatment Responses to PegIntron/RBV for Elderly Patients and by Patient Ethnicity - (11/02/06)
     
     
  29. AASLD: VX-950 HCV Protease Inhibitor Resistance Profile: combination therapy suppresses drug resistance - (11/01/06)
     
     
  30. AASLD: New Drug Lowers AST/ALT Levels in Chronic HCV - (11/01/06)
     
     
  31. AASLD: Albuferon Phase 2 Study Results Reported in Posters at AASLD - (11/01/06)
     
     
  32. AASLD: Albuferon Quality-Of-Life Reported - (11/01/06)
     
     

AASLD Coverage From : NATAP

http://www.natap.org/

From: HCV Advocate

AASLD 2006 Onsite Coverage


Oct 2006


Routine Laboratory Data Can Help Predict Advanced Liver Fibrosis in HIV-HCV Coinfected Patients

Baseline viral load (400,000 IU/mL) as a predictor of SVR rate with peginterferon alfa-2a (40KD) (PEGASYS) plus ribavirin (COPEGUS) in HCV/HIV Coinfected in Apricot Study

Non-viral Factors Associated with HCV Recurrence after Liver Transplantation

Hepatitis C Treatment after Liver Transplantation

Life Expectancy after Liver Transplantation

Heavy smoking and liver

4-Week Response to Anti-HCV Treatment Predicts Outcome

HCV Polymerase Inhibitor R-1626 Advances to Phase II Study

Liver Fibrosis in Women with Chronic Hepatitis C

The Nucleoside Inhibitor MK-0608 Mediates Suppression of HCV Replication for >30 Days in Chronically Infected Chimpanzees - 10/02/06

HCV Drug Pipeline updated October 5, 2006

Immunological Control of Hepatitis C Virus during Acute Infection

HCV Core Protein Linked to Immune Evasion in Liver Cells

Organ Transplant Centers Face Federal Scrutiny

Liver Toxicity Associated with Ritonavir-boosted Tipranavir

World Hepatitis Awareness Day

Women Given Liver Transplants Outlive Male Recipients By Around 4 Years

16-week Treatment May Be Adequate for Genotype 2 Hepatitis C Patients

IP-10 Levels Predict Treatment Response in Patients with Hepatitis C

Social and Behavioral Factors Associated with HCV Transmission in Injection Drug Users

LDL Receptor Levels, Alcohol Consumption, and HCV Viral Load in Hepatitis C Patients

Causes of Death after Diagnosis of Hepatitis B or C

Viral Clearance and Disease Progression in Siblings with Hepatitis C

Spleen Removal Can Help Hepatitis C Patients with Cirrhosis Tolerate Treatment
 


Sept 2006


Insulin resistance and HCV: Will new knowledge modify clinical management? -

09/21/06

GAY MEN AND HEP C -

NIM811, a Cyclophilin Inhibitor, Exhibits Potent In Vitro Activity against Hepatitis C Virus Alone or in Combination with Alpha Interferon

ViroPharma Announces Positive Data From Phase 1b Combination Study Of HCV-796 And Pegylated Interferon In Hepatitis C Patients -

Hispanics Have More Aggressive Liver Disease in LA County Hepatitis Clinic

DDW 2006: Conference Highlights – Part 3

HealthWise: Dietary Supplements

Statins: A New Therapy for Hepatitis C?

Hepatotoxicity From Statin Therapy

Statins May Trigger Autoimmune Hepatitis

Excerpt: MANAGEMENT OF HEPATITIS C BY THE PRIMARY CARE PROVIDER: MONITORING GUIDELINES

No Link Found between Hepatitis C Infection and Heart Attacks

Can Hepatitis C Be Transmitted by Sharing Toothbrushes?

Mutation Patterns and Genotypes Associated with Hepatocellular Carcinoma in HBV/HCV Coinfected Patients

Vaccination against hepatitis A and B: developments, deployment and delusions

Hepatitis In Primary Care:What Physician Assistants Can Do To Help Save Million

72-Week Treatment More Effective than 48 Weeks for Patients with Detectable HCV Viral Load at Week 4

No Evidence of Hepatitis C Virus Recombination in Superinfected Patients

ViroPharma and Wyeth Announce Achievement of "Proof of Concept" Milestone for HCV-796, Phase II Study to Begin Soon

Study Confirms Poorer Interferon Treatment Response in African Americans
 


Aug 2006


HealthWise: Healthy Living with HCV Series Part 4 — Tipping the Scales towards Successful Weight Loss

New HCV Antivirals and Drug Resistance

DDW 2006: Conference Highlights – Part 2

Efficacy of Low-dose Peg-Intron

HCV Death Rate Doubles Among IDUs in Last 5 Years

Peregrine's Final HCV Phase 1a Study Results Accepted for Oral Presentation at AASLD Annual Meeting -

Distribution of Hepatitis C Virus Genotypes and Viral Load Levels in the U.S.

Cost effectiveness of interferon or peginterferon with ribavirin for histologically mild chronic hepatitis C -

Is HCV Infection Associated with Liver Steatosis in Children?

Gene Response to Interferon Therapy for Hepatitis C Differs by Race

Study Confirms Poorer Interferon Treatment Response in African Americans

Relation between LDL Cholesterol Levels and Hepatitis C Treatment Outcomes

Predictors of Sexual Transmission of HCV in Gay Men

Non-invasive Assessment of Liver Fibrosis in Patients with Hepatitis C

Long-term Effect of Interferon/Ribavirin on Incidence of Hepatocellular Carcinoma

Cost effectiveness of interferon or peginterferon with ribavirin for histologically mild chronic hepatitis C -

72 Weeks Pegasys/RBV Improves SVR for When HCV-RNA is Detectable at Week 4 -

Diabetes is Associated with Hepatic Encephalopathy in Patients with HCV-Related Cirrhosis

Pegylated Interferon Plus Ribavirin Therapy in Patients with HCV Recurrence after Liver Transplantation

Thyroid Dysfunction in Chronic Hepatitis C Patients Treated with Interferon/Ribavirin

Pegasys/RBV in African-Americans -

Hepatic fibrosis in Hispanics

Hepatitis C Virus Detection Using HCV RNA Qualitative (TMA) Testing in the HALT-C Trial

HCV RNA detection by TMA during the hepatitis C antiviral long-term treatment against cirrhosis (Halt-C) trial

A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content

CDC Study on HCV Risk Transmission & Tattoos/Body Piercing, Snorting Drugs -

Age Alone Does Not Affect Outcome of Liver Transplant in Elderly

Genetic Variation and Hepatitis C

New HCV Antivirals and Drug Resistance

FDA Warns About Eating Raw Wash. Oysters

Effect of Tattooing, Body Piercing and Intranasal Drug Use on Risk of HCV & HBV

Interferon Enhancer Drug EMZ702 Study + PegIFN/RBV -

Natural History of Liver Cirrhosis Due to Hepatitis C

 


July 2006


Lifestyle changes and beliefs regarding disease severity in patients with chronic hepatitis C.

Stuck With Hepatitis

Hispanics with Chronic Hepatitis C May Develop More Advanced Fibrosis
 

Detection of HCV RNA in the Livers of Patients with "Undetectable" Viral Load and Normal ALT

Sexual Problems in Men with Hepatitis C

Extrahepatic replication of HCV: Insights into clinical manifestations and biological consequences -

The Role of CD4 and CD8 T-Cells in Spontaneous Clearance of Hepatitis C Virus

Statin Drugs Inhibit HCV in vitro

Smoking May Worsen Liver Fibrosis in Patients with Hepatitis C

Retreatment and Long-Term Follow-Up of Nonresponders

Extra-Strength Acetaminophen Can Cause Liver Inflammation in People without Liver Disease
 

Impact of Alcohol Use on Hepatitis C Treatment Outcomes and Quality of Life

Natural History of Chronic Hepatitis C in Patients Age 65 and Older

Hepatitis Induced by Noni Juice from Morinda citrifolia

CLINICAL MANIFESTATIONS OF LIVER DISEASE

Phase 2 Study of VX-950, Pegasys, and Copegus in Hepatitis C- study sites

Hepatic Steatosis Is Associated with Fibrosis, Nucleoside Analogue Use, and Hepatitis C Virus Genotype 3 Infection in HIV-Seropositive Patients: Steatosis was present in 69% of patients

BREASTFEEDING & HCV TRANSMISSION

Drug Resistance Wksp: Coffee, Cirrhosis, and Transaminase Enzymes

HCV ADVOCATE WEEKLY NEWS REVIEW

News 2005 News 2004

2003 Research News and Articles

HCV News Archives 2001-2002


June 2006


Fibrosis progression in initially mild chronic hepatitis C

From DDW

BMI, Insulin Resistance Contribute to Fibrosis -

 (06/12/06)

Thiazolidinediones and hepatic fibrosis: don't wait too long -

(06/12/06)

 

HCV is Detected in Liver of HCV Antibody-Positive But HCV RNA Negative Patients, so don't assume HCV has been cleared if viral load is undetectable -

06/08/06

EASL: 5 Year Followup of SVRs with PegIntron/RBV-98% Continued SVR5 -
 

Sexual Dysfunction is Highly Prevalent Among Men with Chronic Hepatitis C Virus Infection and Negatively Impacts Health-Related Quality of Life -

06/07/06

Study Finds Diabetes is Associated with HCV & HBV, Triglycerides, Steatosis & More Severe Fibrosis -

06/07/06

Peginterferon alfa-2a (Pegasys) and ribavirin for chronic hepatitis C genotype 1 infections in black patients: safety, tolerability and impact on sustained virologic response -

06/06/06


DDW: The Impact of Growth Factors on Pegylated Interferon alfa-2b and Ribavirin Dose Reduction in Patients Treated for Genotype 1 Chronic Hepatitis C -

06/06/06

Novartis strengthens infectious disease portfolio by acquiring rights to Albuferon(TM), a hepatitis C interferon drug set to enter Phase III trials -

06/06/06

DDW: Preclinical Characteristics of ITMN-191, an Orally Active Inhibitor of the HCV NS3/4A Protease Nominated for Preclinical Development -

06/06/06

DDW: Pharmacokinetic Analysis and Liver Concentrations of a Series of Macrocyclic Peptidomimetic Inhibitors of HCV NS3/4A Protease: Identification of ITMN-191, a Potent NS3/4A Protease Inhibitor with High Liver Exposure Across Multiple Species -

 06/06/06

DDW: Growth Factors Versus Dose Reduction for Pegylated Interferon alfa-2b and Ribavirin-Associated Neutropenia and Anemia in HIV/HCV Co-Infected Patients -

6-06-06

Blood Cell Growth Factors Improve Adherence and SVR Rates - 6/06/06

CPG 10101: Promising Data at 12 Weeks in Prior Relapsers -

 6/06/06

Celgosivir: Well-Tolerated, but Minimal Anti-HCV Activity as Monotherapy -

 6/06/06

Factors Influencing Treatment Response in WIN-R Trial-

6/02/06

Preclinical Data on New HCV Protease Inhibitor ITMN 191-

6/02/06

Treating Obesity May Improve the Efficacy of Therapy for Hepatitis C

Largest U.S. Hepatitis C Trial Provides Insight Into Optimizing Treatment

Fatigue Is a Major Problem After Liver Transplantation

DDW Special Report: VX-950


May 2006


12 of 12 Patients Receiving Experimental HCV Protease Inhibitor VX 950 in Combination with Pegasys Plus Ribavirin for 28 Days Experience Undetectable HCV RNA Levels

Guidelines for the Management of Hepatitis C Virus Infection

Roche study shows hepatitis C patients need six months of treatment

Detection of HCV RNA Using Sensitive Test Can Help Guide Therapy-

5/30/06

Predictors of Sustained Response to Peg-Intron or Pegasys Plus Ribavirin-

 5/30/06

Polymerase Inhibitor HCV-796 Demonstrates Potent Antiviral Activity-

5/30/06

In Nonresponders to Peginterferon/Ribavirin, Valopicitabine + Peginterferon at Optimal Dosing Produces Significantly Greater HCV Suppression Compared to Retreatment with Peginterferon Alfa-

5/26/06

Update on New Therapies

Psychological and Social Aspects of Hepatitis C Treatment

HEPATITIS: THE SILENT PANDEMIC
 

Duration of Peginterferon Therapy in Acute Hepatitis C

Factors That Predict a Rapid Virological Response at Week 4 and a Sustained Virological Response at Week 24

SUSTAINED VIROLOGIC RESPONSE (SVR) TO INTERFERON-ALFA-2B+/- RIBAVIRIN THERAPY AT 6 MONTHS RELIABLY PREDICTS LONG-TERM CLEARANCE OF HCV AT 5-YEAR FOLLOW UP

Comparison of 48 vs 72 Weeks of Treatment with Peginterferon Alfa-2a plus Ribavirin in Patients with HCV Genotype 1


HIV and Hepatitis.com
Coverage of
Digestive Disease Week 2006 (DDW 2006)
May 20 - 25, 2006, Los Angeles, California

Retreatment with Peginterferon Alfa-2a (Pegasys) Plus Ribavirin of Nonresponders with Cirrhosis/Advanced Fibrosis to Peginterferon Alfa-2b (PegIntron) - 5/23/06

Differences in Outcomes of Treatment with PegIntron Plus Fixed-dose or Weight-based Ribavirin Based on Genotype and Viral Load in HCV Genotypes 2 and 3 in The WIN-R Trial - 5/23/06

Cost-Effectiveness of First-Line Pegasys Plus Ribavirin in Patients with Mild Chronic Hepatitis C (CHC) in the US HC - 5/23/06

The Effect of Liver Fibrosis and Cirrhosis on SVR in 4913 Patients with Hepatitis C: Results from the Win-R Trial - 5/23/06

Initial HCV Response in Patients with End Stage Renal Disease Treated with Pegasys Plus Ribavirin - 5/23/06

Evaluation of a HCV Patient Support Program’s Impact on Patient Adherence - 5/23/06

Schering-Plough Announces Hepatitis C Data Presentations at Digestive Disease Week 2006 (DDW 2006) 37th Annual Meeting in Los Angeles -5-19-06

 

 

April 2006


Who Tattoos? Anyone who wants to, say critics seeking better regulations

Liver Biopsy Not Foolproof

Treatment-related Depression Is the Most Significant Factor Affecting Health-related Quality of Life in Chronic Hepatitis C

Risk Factors for Graft Survival After Liver Transplantation From Donation
After Cardiac Death Donors: An Analysis of OPTN/UNOS Data

Does Use of Complementary Treatments with Peginterferon plus Ribavirin Combination Therapy Provide a Benefit to Patients with Chronic Hepatitis C?

Blacks with HCV Genotype 1 (but Not Genotypes 2 or 3) Have a Lower SVR Rate Than Non-Blacks That Is Not Related to Dose Reductions of Interferon and Ribavirin

What Actually Happens to Patients Newly Diagnosed with Hepatitis C Virus Infection?

“A la Carte” Hepatitis C Therapy


March 2006


Factor XIII Deficiency Associated with Reduced Survival in Cirrhosis

New Compound May Protect Against Liver Cancer

Validation of Cardiovascular Risk Scores for Liver Transplants

Vertex's Hepatitis C Drug Has 'Gold Standard' Potential
 


February 2006


Battle of the New, Non-invasive Measures of Fibrosis: FibroScan versus FibroTest

Thalidomide May Be Effective in Chronic Hepatitis C Unresponsive to Interferon and Ribavirin

Improved Pegylated-Interferons and Anti-Virals Key to Driving Uptake and Increase Treatment Rates

Peregrine Announces Completion of Planned Patient Enrollment and Dosing in Initial Tarvacin(TM) Anti-Viral Hepatitis C Phase 1 Trial

Living in the Long, Dark Shadow of Hep C

Living Donor Liver Transplant in High-Risk Patients Is Effective

Longer Esophageal Variceal Ligation Intervals Reduce Rebleeds

Ethnic Differences in the Presentation of Chronic Hepatitis C


January 2006


 
HCV Link to Cancer Found
 
Chronic Hepatitis C Treatment, Peg-Intron(R) And Rebetol(R) Approved In Japan

Top Eleven News Stories of 2005 (updated)

Information about current HCV medical treatment, factors that influence disease progression and the long term sustainability of successful HCV treatment.

HealthWise: To Treat or not to Treat — That is the Question

Liver Transplantation

 

 

   
 

News 2005

News 2004

2003 Research News and Articles

HCV News Archives 2001-2002

 

 

 

 

 
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Reviewed Dec 5 2006